课程介绍

 

　　Large-scalebiologyprojectssuchasthesequencingofthehumangenomeandgeneexpressionsurveysusingRNA-seq,microarraysandothertechnologieshavecreatedawealthofdataforbiologists.However,thechallengefacingscientistsisanalyzingandevenaccessingthesedatatoextractusefulinformationpertainingtothesystembeingstudied.Thiscoursefocusesonemployingexistingbioinformaticresources–mainlyweb-basedprogramsanddatabases–toaccessthewealthofdatatoanswerquestionsrelevanttotheaveragebiologist,andishighlyhands-on.Topicscoveredincludemultiplesequencealignments,phylogenetics,geneexpressiondataanalysis,andproteininteractionnetworks,intwoseparateparts.Thefirstpart,BioinformaticMethodsI(thisone),dealswithdatabases,Blast,multiplesequencealignments,phylogenetics,selectionanalysisandmetagenomics.This,thesecondpart,BioinformaticMethodsII,coversmotifsearching,protein-proteininteractions,structuralbioinformatics,geneexpressiondataanalysis,andcis-elementpredictions.Thispairofcoursesisusefultoanystudentconsideringgraduateschoolinthebiologicalsciences,aswellasstudentsconsideringmolecularmedicine.Bothprovideanoverviewofthemanydifferentbioinformatictoolsthatareoutthere.ThesecoursesarebasedononetaughtattheUniversityofTorontotoupper-levelundergraduateswhohavesomeunderstandingofbasicmolecularbiology.Ifyou'renotfamiliarwiththis,somethinglikehttps://learn.saylor.org/course/bio101mightbehelpful.Noprogrammingisrequiredforthiscourse.

 

　　课程目录

 

　　1NCBI/BlastI

 

　　1.1Introduction

 

　　1.2Lecture

 

　　1.3Labdiscussion

 

　　1.4Summary

 

　　2BlastII-ComparativeGenomics

 

　　2.1Introduction

 

　　2.2Lecture

 

　　2.3Labdiscussion

 

　　2.4Summary

 

　　3MultipleSequenceAlignments

 

　　3.1Introduction

 

　　3.2Lecture

 

　　3.3Labdiscussion

 

　　3.4Summary

 

　　4Phylogenetics

 

　　4.1Introduction

 

　　4.2Lecture

 

　　4.3Labdiscussion

 

　　4.4Summary

 

　　5SelectionAnalysis

 

　　5.1Introduction

 

　　5.2Lecture

 

　　5.3Labdiscussion

 

　　5.4Summary

 

　　6'NextGen'SequenceAnalysis(RNA-seq)-Metagenomics

 

　　6.1Introduction

 

　　6.2Lecture

 

　　6.3Labdiscussion

 

　　6.4Summary